Soluble Factors Released by Toxoplasma gondii-Infected Astrocytes Down-Modulate Nitric Oxide Production by Gamma Interferon-Activated Microglia and Prevent Neuronal Degeneration

The maintenance of a benign chronic Toxoplasma gondii infection is mainly dependent on the persistent presence of gamma interferon (IFN-γ) in the central nervous system (CNS). However, IFN-γ-activated microglia are paradoxically involved in parasitism control and in tissue damage during a broad rang...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Rozenfeld, Claudia, Martinez, Rodrigo, Figueiredo, Rodrigo T., Bozza, Marcelo T., Lima, Flávia R. S., Pires, Ana Lúcia, Silva, Patrícia M., Bonomo, Adriana, Lannes-Vieira, Joseli, De Souza, Wanderley, Moura-Neto, Vivaldo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Host Response and Inflammation
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.4.2047-2057.2003
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