Interleukin-10 Negatively Regulates Local Cytokine and Chemokine Production but Does Not Influence Antibacterial Host Defense during Murine Pneumococcal Meningitis

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemoki...

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में प्रकाशित:	Infect Immun
मुख्य लेखकों:	Zwijnenburg, Petra J. G., van der Poll, Tom, Florquin, Sandrine, Roord, John J., van Furth, A. Marceline
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology (ASM) 2003
विषय:	Host Response and Inflammation
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152042/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654856/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.4.2276-2279.2003
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