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Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
Leptin controls feeding behavior and insulin secretion from pancreatic β-cells. Insulin stimulates the production of leptin, thereby establishing an adipoinsular axis. Earlier we identified leptin receptors on pancreatic β-cells and showed leptin-mediated inhibition of insulin secretion by activatio...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
1999
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC15195/ https://ncbi.nlm.nih.gov/pubmed/9892692 |
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