Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse

Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) in skewed gene expression and disease pathogenesis. We used the MRL-lpr/lpr murine model of lupus to demonstrate that HDACs play a key role in the heightened levels of both Th1 and Th2 cytoki...

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Pubblicato in:	J Clin Invest
Autori principali:	Mishra, Nilamadhab, Reilly, Christopher M., Brown, Doris R., Ruiz, Phil, Gilkeson, Gary S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2003
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16153
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