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Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) in skewed gene expression and disease pathogenesis. We used the MRL-lpr/lpr murine model of lupus to demonstrate that HDACs play a key role in the heightened levels of both Th1 and Th2 cytoki...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151922/ https://ncbi.nlm.nih.gov/pubmed/12588892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316153 |
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