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Flexibility of the Neck Domain Enhances Kinesin-1 Motility under Load
Kinesin-1 is a dimeric motor protein that moves stepwise along microtubules. A two-stranded α-helical coiled-coil formed by the neck domain links the two heads of the molecule, and forces the motor heads to alternate. By exchanging the particularly soft neck region of the conventional kinesin from t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Biophysical Society
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1518645/ https://ncbi.nlm.nih.gov/pubmed/16714343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.076265 |
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