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Flexibility of the Neck Domain Enhances Kinesin-1 Motility under Load

Kinesin-1 is a dimeric motor protein that moves stepwise along microtubules. A two-stranded α-helical coiled-coil formed by the neck domain links the two heads of the molecule, and forces the motor heads to alternate. By exchanging the particularly soft neck region of the conventional kinesin from t...

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Detalhes bibliográficos
Main Authors: Jaud, Johann, Bathe, Friederike, Schliwa, Manfred, Rief, Matthias, Woehlke, Günther
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518645/
https://ncbi.nlm.nih.gov/pubmed/16714343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.076265
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