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Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

A pathogenic hallmark of rheumatoid arthritis (RA) is persistent activation of self-reactive CD4(+) T cells. The cause of this aberrant activity remains elusive. We report here detection of autoantibodies against B7-H1, a recently described member of the B7 family, in 29% of patients with RA versus...

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Udgivet i:J Clin Invest
Principais autores: Dong, Haidong, Strome, Scott E., Matteson, Eric L., Moder, Kevin G., Flies, Dallas B., Zhu, Gefeng, Tamura, Hideto, Driscoll, Colin L.W., Chen, Lieping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151851/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12569162/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16015
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