Presence of autoantibodies targeting the shared epitope in rheumatoid arthritis and psoriatic arthritis

IntroductionRheumatoid arthritis (RA) is an autoimmune disease marked by the production of autoantibodies (AAb) against citrullinated proteins/peptides (ACPA). The shared epitope (SE) in the HLA-DRB1 gene is a major genetic risk factor for RA and has been linked to ACPA production, particularly in i...

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Autori principali:	Eduard Graell, Juan Francisco Delgado, Antonio Domingo Gomez, Maria García-Marique, Menna Rusiñol, Albert Rodrigo, Antoni Berenguer-Llergo, Jordi Gratacos, Joan Calvet
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	anti-citrullinated peptide antibodies autoantibodies inflammatory arthritis rheumatoid arthritis shared epitope
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1744370/full
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