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Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel homeostasis was investigated. Systemic infusion of an adenovirus encoding a dominant negative mutant of PI 3-K (Δp85) resulted in liver-specific expression of this protein and in inhibition of the insuli...

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Main Authors: Miyake, Kazuaki, Ogawa, Wataru, Matsumoto, Michihiro, Nakamura, Takehiro, Sakaue, Hiroshi, Kasuga, Masato
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC151813/
https://ncbi.nlm.nih.gov/pubmed/12438446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15880
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