RWJ-54428 (MC-02,479), a New Cephalosporin with High Affinity for Penicillin-Binding Proteins, Including PBP 2a, and Stability to Staphylococcal Beta-Lactamases

RWJ-54428 (MC-02,479) is a new cephalosporin active against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The potency of this new cephalosporin against MRSA is related to a high affinity for penicillin-binding protein 2a (PBP 2a), as assessed in a competition...

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Bibliographic Details
Main Authors: Malouin, Francois, Blais, Johanne, Chamberland, Suzanne, Hoang, Monica, Park, Craig, Chan, Christin, Mathias, Kristina, Hakem, Samia, Dupree, Kelly, Liu, Eric, Nguyen, Tien, Dudley, Michael N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151748/
https://ncbi.nlm.nih.gov/pubmed/12543674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.2.658-664.2003
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