Suboptimal Antibiotic Dosage as a Risk Factor for Selection of Penicillin-Resistant Streptococcus pneumoniae: In Vitro Kinetic Model

Optimizing pharmacokinetic/pharmacodynamic indices of antibiotics to obtain clinical and microbiological efficacy is essential, but dosing regimens must also be tailored to minimize the risk for emergence of resistance. The aim of the present study was to investigate whether certain concentrations o...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Odenholt, Inga, Gustafsson, Ingegerd, Löwdin, Elisabeth, Cars, Otto
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Experimental Therapeutics
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12543652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.2.518-523.2003
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