Enhanced Genomic Instability and Defective Postreplication Repair in RAD18 Knockout Mouse Embryonic Stem Cells

In lower eukaryotes, Rad18 plays a crucial role in postreplication repair. Previously, we isolated a human homologue of RAD18 (hRAD18) and showed that human cells overexpressing hRad18 protein with a mutation in the RING finger motif are defective in postreplication repair. Here, we report the const...

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Detalhes bibliográficos
Main Authors: Tateishi, Satoshi, Niwa, Hitoshi, Miyazaki, Jun-Ichi, Fujimoto, Shiho, Inoue, Hirokazu, Yamaizumi, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151530/
https://ncbi.nlm.nih.gov/pubmed/12509447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.2.474-481.2003
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