Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8(+) T cells in influenza virus-infected mice

Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependent CD8(+) CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the me...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Johnson, Barbara J., Costelloe, Elaine O., Fitzpatrick, David R., Haanen, John B. A. G., Schumacher, Ton N. M., Brown, Lorena E., Kelso, Anne
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12601154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0538056100
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