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Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8(+) T cells in influenza virus-infected mice

Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependent CD8(+) CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the me...

Celý popis

Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Johnson, Barbara J., Costelloe, Elaine O., Fitzpatrick, David R., Haanen, John B. A. G., Schumacher, Ton N. M., Brown, Lorena E., Kelso, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151396/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12601154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0538056100
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