Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase

Using small-angle x-ray scattering, we have observed the cGMP-induced elongation of an active, cGMP-dependent, monomeric deletion mutant of cGMP-dependent protein kinase (Δ(1–52)PKG-Iβ). On saturation with cGMP, the radius of gyration of Δ(1–52)PKG-Iβ increases from 29.4 ± 0.1 Å to 40.1 ± 0.7 Å, and...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Wall, Michael E., Francis, Sharron H., Corbin, Jackie D., Grimes, Kennard, Richie-Jannetta, Robyn, Kotera, Jun, Macdonald, Brian A., Gibson, Rowena R., Trewhella, Jill
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2003
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151349/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12591946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0534892100
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