Retroevolution of λ Cro toward a stable monomer
The Cro protein from bacteriophage λ has a dimeric α+β fold that evolved from an ancestral all-α monomer. The sequence mutations responsible for this dramatic structural evolution are unknown. Here we use analysis of sequence alignments to show that Ala-33, a small side chain in the hydrophobic “bal...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12598646/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0537925100 |
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