Retroevolution of λ Cro toward a stable monomer
The Cro protein from bacteriophage λ has a dimeric α+β fold that evolved from an ancestral all-α monomer. The sequence mutations responsible for this dramatic structural evolution are unknown. Here we use analysis of sequence alignments to show that Ala-33, a small side chain in the hydrophobic “bal...
-д хадгалсан:
| -д хэвлэсэн: | Proc Natl Acad Sci U S A |
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| Үндсэн зохиолчид: | , |
| Формат: | Artigo |
| Хэл сонгох: | Inglês |
| Хэвлэсэн: |
National Academy of Sciences
2003
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| Нөхцлүүд: | |
| Онлайн хандалт: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12598646/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0537925100 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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