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Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance

BACKGROUND: Studies indicate that thymidylate synthase (TS) expression, p53 and mismatch repair status have potential to influence colorectal cancer (CRC) outcome. There is, however, little data on the inter-relationship between these three markers. We sought to investigate whether relationships exi...

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Detalhes bibliográficos
Main Authors: Popat, Sanjay, Wort, Richard, Houlston, Richard S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1513242/
https://ncbi.nlm.nih.gov/pubmed/16753067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-150
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