A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins α(v)β(3) and α(IIb)β(3)

The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes. Sequence analysis of the speB gene from 200 group A Streptococcus isolates collected worldwi...

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Main Authors: Stockbauer, Kathryn E., Magoun, Loranne, Liu, Mengyao, Burns, Eugene H., Gubba, Siddeswar, Renish, Sarah, Pan, Xi, Bodary, Sarah C., Baker, Elizabeth, Coburn, Jenifer, Leong, John M., Musser, James M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC15124/
https://ncbi.nlm.nih.gov/pubmed/9874803
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