Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4

We investigated the interaction between angiogenic and osteogenic factors in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or VEGF-specific antagonist (soluble Flt1). Our re...

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Hlavní autoři: Peng, Hairong, Wright, Vonda, Usas, Arvydas, Gearhart, Brian, Shen, Hsain-Chung, Cummins, James, Huard, Johnny
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2002
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151123/
https://ncbi.nlm.nih.gov/pubmed/12235106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15153
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