The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes, and Focal Creatine Deposits

Cytosolic brain-type creatine kinase (BB-CK), which is coexpressed with ubiquitous mitochondrial uMtCK, is significantly inactivated by oxidation in Alzheimer's disease (AD) patients. Since CK has been shown to play a fundamental role in cellular energetics of the brain, any disturbance of this...

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Hlavní autoři: Bürklen, Tanja S., Schlattner, Uwe, Homayouni, Ramin, Gough, Kathleen, Rak, Margaret, Szeghalmi, Adriana, Wallimann, Theo
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2006
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Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510941/
https://ncbi.nlm.nih.gov/pubmed/17047305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/JBB/2006/35936
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