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Protein motion from non-specific to specific DNA by three-dimensional routes aided by supercoiling

DNA-binding proteins are generally thought to locate their target sites by first associating with the DNA at random and then translocating to the specific site by one-dimensional (1D) diffusion along the DNA. We report here that non-specific DNA conveys proteins to their target sites just as well wh...

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Detalhes bibliográficos
Main Authors: Gowers, Darren M., Halford, Stephen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151056/
https://ncbi.nlm.nih.gov/pubmed/12628933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg125
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