Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells.

1. Cyclo-oxygenase (COX) and nitric oxide synthase (NOS) are two enzymes which have distinct cytokine-inducible isoforms (COX-2 and iNOS). Many cytokine receptors have an intracellular tyrosine kinase domain. Here we have used the tyrosine kinase inhibitors, erbstatin and genistein, to investigate t...

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Main Authors: Akarasereenont, P, Mitchell, J A, Appleton, I, Thiemermann, C, Vane, J R
Formato: Artigo
Idioma:Inglês
Publicado: 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510522/
https://ncbi.nlm.nih.gov/pubmed/7534189
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