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Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
Griscelli syndrome (GS) patients and the corresponding mouse model ashen exhibit defects mainly in two types of lysosome-related organelles, melanosomes in melanocytes and lytic granules in CTLs. This disease is caused by loss-of-function mutations in RAB27A, which encodes 1 of the 60 known Rab GTPa...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151050/ https://ncbi.nlm.nih.gov/pubmed/12122117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15058 |
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