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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway leading from mevalonate to cholesterol. This study suggests that, in osteoclasts, geranylgeranyl diphosphate, the substrate for prenylation of most GTP binding proteins, is...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fisher, J. E., Rogers, M. J., Halasy, J. M., Luckman, S. P., Hughes, D. E., Masarachia, P. J., Wesolowski, G., Russell, R. G. G., Rodan, G. A., Reszka, A. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1999
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15105/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.133
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