The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro.

1. A series of isoquinolines have been identified as 5-HT3 receptor antagonists. One of these, RS 25259-197 [(3aS)-2-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro- 1- oxo-1H-benzo[de]isoquinoline-hydrochloride], has two chiral centres. The remaining three enantiomers are denoted as RS 252...

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Detaylı Bibliyografya
Asıl Yazarlar: Wong, E H, Clark, R, Leung, E, Loury, D, Bonhaus, D W, Jakeman, L, Parnes, H, Whiting, R L, Eglen, R M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1995
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510197/
https://ncbi.nlm.nih.gov/pubmed/7773546
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