Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

TGF-βs play diverse and complex roles in many biological processes. In tumorigenesis, they can function either as tumor suppressors or as pro-oncogenic factors, depending on the stage of the disease. We have developed transgenic mice expressing a TGF-β antagonist of the soluble type II TGF-β recepto...

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Detalhes bibliográficos
Main Authors: Yang, Yu-an, Dukhanina, Oksana, Tang, Binwu, Mamura, Mizuko, Letterio, John J., MacGregor, Jennifer, Patel, Sejal C., Khozin, Shahram, Liu, Zi-yao, Green, Jeffrey, Anver, Miriam R., Merlino, Glenn, Wakefield, Lalage M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151015/
https://ncbi.nlm.nih.gov/pubmed/12070308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15333
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