Mutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists.

Chimeric constructs between the human and the Xenopus laevis AT1 receptor have demonstrated, that the binding of non-peptide angiotensin antagonists is dependent on non-conserved residues located deep in transmembrane segment VII of the AT1 receptor. Here we have studied four pairs of closely relate...

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Hauptverfasser: Schambye, H T, von Wijk, B, Hjorth, S A, Wienen, W, Entzeroth, M, Bergsma, D J, Schwartz, T W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510146/
https://ncbi.nlm.nih.gov/pubmed/7834178
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