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Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90

Although Hsp90 displays general chaperone activity in vitro, few substrates of the chaperone have been identified in vivo, and the characteristics that render these substrates dependent on Hsp90 remain elusive. To investigate this issue, we exploited a paradoxical observation: several unrelated onco...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Xu, Yang, Singer, Mike A., Lindquist, Susan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 1999
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC15101/
https://ncbi.nlm.nih.gov/pubmed/9874780
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