Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal plasticity. In this study we demonstrate that endogenous tPA mediates the progression of kainic acid–induced (KA-induced) seizures by promoting the synchronization...

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Publicado en:	J Clin Invest
Autores principales:	Yepes, Manuel, Sandkvist, Maria, Coleman, Timothy A., Moore, Elizabeth, Wu, Jiang-Young, Mitola, David, Bugge, Thomas H., Lawrence, Daniel A.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2002
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151009/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12070304/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14308
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