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Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval

Regulatory subunit KCNE3 (E3) interacts with KCNQ1 (Q1) in epithelia, regulating its activation kinetics and augmenting current density. Since E3 is expressed weakly in the heart, we hypothesized that ectopic expression of E3 in cardiac myocytes might abbreviate action potential duration (APD) by in...

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Bibliografski detalji
Glavni autori: Mazhari, Reza, Nuss, H. Bradley, Armoundas, Antonis A., Winslow, Raimond L., Marbán, Eduardo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC150950/
https://ncbi.nlm.nih.gov/pubmed/11956246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15062
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