The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy, and disarray. To understand the early consequences of mutant sarcomere proteins, we have studied mice (designated αMHC(403/+))...

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Hauptverfasser: Semsarian, Christopher, Ahmad, Imran, Giewat, Michael, Georgakopoulos, Dimitrios, Schmitt, Joachim P., McConnell, Bradley K., Reiken, Steven, Mende, Ulrike, Marks, Andrew R., Kass, David A., Seidman, Christine E., Seidman, J.G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150949/
https://ncbi.nlm.nih.gov/pubmed/11956238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14677
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