Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation

LMX1B encodes a LIM-homeodomain transcription factor. Mutations in LMX1B cause nail-patella syndrome (NPS), an autosomal dominant disease with skeletal abnormalities, nail hypoplasia, and nephropathy. Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b(–/–) mice, suggestin...

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Bibliografiske detaljer
Main Authors: Miner, Jeffrey H., Morello, Roy, Andrews, Kaya L., Li, Cong, Antignac, Corinne, Shaw, Andrey S., Lee, Brendan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150942/
https://ncbi.nlm.nih.gov/pubmed/11956244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13954
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