IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and allograft rejection. To test the hypothesis that IL-15–deficient (IL-15(–/–)) mice would be protected from T cell–dependent nephritis, we induced nephrotoxic serum nephritis (NSN) in IL-15(–/–) and wild-type (IL-1...

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Detalhes bibliográficos
Main Authors: Shinozaki, Michiya, Hirahashi, Junichi, Lebedeva, Tatiana, Liew, Foo Y., Salant, David J., Maron, Ruth, Kelley, Vicki Rubin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150930/
https://ncbi.nlm.nih.gov/pubmed/11927622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14574
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