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Mutagenesis of conserved lysine residues in bacteriophage T5 5′-3′ exonuclease suggests separate mechanisms of endoand exonucleolytic cleavage

Efficient cellular DNA replication requires the activity of a 5′-3′ exonuclease. These enzymes are able to hydrolyze DNA⋅DNA and RNA⋅DNA substrates exonucleolytically, and they are structure-specific endonucleases. The 5′-3′ exonucleases are conserved in organisms as diverse as bacteriophage and mam...

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Bibliografske podrobnosti
Main Authors: Garforth, Scott J., Ceska, Thomas A., Suck, Dietrich, Sayers, Jon R.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC15089/
https://ncbi.nlm.nih.gov/pubmed/9874768
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