Unusually wide co-factor tolerance in a metalloenzyme; divalent metal ions modulate endo–exonuclease activity in T5 exonuclease

T5 5′–3′ exonuclease is a member of a homologous group of 5′ nucleases which require divalent metal co-factors. Structural and biochemical studies suggest that single-stranded DNA substrates thread through a helical arch or hole in the protein, thus bringing the phosphodiester backbone into close pr...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Garforth, Scott J., Patel, Dipak, Feng, Min, Sayers, Jon R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11433022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.13.2772
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