Distinct FTDP-17 Missense Mutations in Tau Produce Tau Aggregates and Other Pathological Phenotypes in Transfected CHO Cells

Multiple tau gene mutations are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), with filamentous tau aggregates as the major lesions in the CNS of these patients. Recent studies have shown that bacterially expressed recombinant tau proteins with...

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Main Authors: Vogelsberg-Ragaglia, Vanessa, Bruce, Jennifer, Richter-Landsberg, Christiane, Zhang, Bin, Hong, Ming, Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15059/
https://ncbi.nlm.nih.gov/pubmed/11102510
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