Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence

The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with poly(-ADP-ribose)polymerase-1, (PARP-1) cleavage, and expression of p53 target genes. The mechanism by whic...

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Autori principali: Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Luo, RuiBai, Samara, Raed, Jung, Mira, Dritschilo, Anatoly, Spoonde, Alexander, Smulson, Mark E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2001
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Brief Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1505598/
https://ncbi.nlm.nih.gov/pubmed/11494111
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