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Poly(ADP-ribosyl)ation of p53 Contributes to TPEN-Induced Neuronal Apoptosis
Depletion of intracellular zinc by N,N,N′,N′-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN) induces p53-mediated protein synthesis-dependent apoptosis of mouse cortical neurons. Here, we examined the requirement for poly(ADP-ribose) polymerase (PARP)-1 as an upstream regulator of p53 in zinc deple...
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| Publicado no: | Mol Cells |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society for Molecular and Cellular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400305/ https://ncbi.nlm.nih.gov/pubmed/25813624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2015.2142 |
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