2-Methoxyestradiol Exhibits a Biphasic Effect on VEGF-A in Tumor Cells and Upregulation Is Mediated Through ER-α: A Possible Signaling Pathway Associated with the Impact of 2-ME(2) on Proliferative Cells

2-Methoxyestradiol (2-ME(2)) was reported to elicit both stimulation and inhibition of tumor angiogenesis and growth depending on the dosage used. However, the mechanism(s) of the biphasic action of 2-ME(2) has been elusive. Here we describe a regulatory role of vascular endothelial growth factor-A...

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Bibliografske podrobnosti
Main Authors: Banerjee, Samarendra N, Sengupta, Krishanu, Banerjee, Snigdha, Saxena, Neela K, Banerjee, Sushanta K
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2003
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502612/
https://ncbi.nlm.nih.gov/pubmed/14670179
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