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Low-dimensional, free-energy landscapes of protein-folding reactions by nonlinear dimensionality reduction

The definition of reaction coordinates for the characterization of a protein-folding reaction has long been a controversial issue, even for the “simple” case in which one single free-energy barrier separates the folded and unfolded ensemble. We propose a general approach to this problem to obtain a...

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Main Authors: Das, Payel, Moll, Mark, Stamati, Hernán, Kavraki, Lydia E., Clementi, Cecilia
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502548/
https://ncbi.nlm.nih.gov/pubmed/16785435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603553103
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