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Low-dimensional, free-energy landscapes of protein-folding reactions by nonlinear dimensionality reduction
The definition of reaction coordinates for the characterization of a protein-folding reaction has long been a controversial issue, even for the “simple” case in which one single free-energy barrier separates the folded and unfolded ensemble. We propose a general approach to this problem to obtain a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502548/ https://ncbi.nlm.nih.gov/pubmed/16785435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603553103 |
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