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Rapid generation of inducible mouse mutants

We have generated an optimized inducible recombination system for conditional gene targeting based on a Cre recombinase–steroid receptor fusion. This configuration allows efficient Cre-mediated recombination in most organs of the mouse upon induction, without detectable background activity. An ES ce...

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Enregistré dans:
Publié dans:Nucleic Acids Res
Auteurs principaux: Seibler, Jost, Zevnik, Branko, Küter-Luks, Birgit, Andreas, Susanne, Kern, Heidrun, Hennek, Thomas, Rode, Anja, Heimann, Cornelia, Faust, Nicole, Kauselmann, Gunther, Schoor, Michael, Jaenisch, Rudolf, Rajewsky, Klaus, Kühn, Ralf, Schwenk, Frieder
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2003
Sujets:
NAR Methods Online
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150244/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12582257/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng012
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