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Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides

DNA minor groove-binding compounds (polyamides) that target insect and vertebrate telomeric repeats with high specificity were synthesized. Base pair recognition of these polyamides is based on the presence of the heterocyclic amino acids pyrrole and imidazole. One compound (TH52B) interacts uniquel...

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Detalhes bibliográficos
Main Authors: Maeshima, Kazuhiro, Janssen, Samuel, Laemmli, Ulrich K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150199/
https://ncbi.nlm.nih.gov/pubmed/11406598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.12.3218
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