Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

The protease granzyme B (GrB) plays a key role in the cytocidal activity during cytotoxic T lymphocyte (CTL)-mediated programmed cell death. Multiple caspases have been identified as direct substrates for GrB, suggesting that the activation of caspases constitutes an important event during CTL-induc...

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Detalhes bibliográficos
Main Authors: Sharif-Askari, Ehsan, Alam, Antoine, Rhéaume, Eric, Beresford, Paul J., Scotto, Christian, Sharma, Kamal, Lee, Dennis, DeWolf, Walter E., Nuttall, Mark E., Lieberman, Judy, Sékaly, Rafick-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150191/
https://ncbi.nlm.nih.gov/pubmed/11406587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.12.3101
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