Two-Mechanism Peak Concentration Model for Cellular Pharmacodynamics of Doxorubicin

A mathematical model is presented for the cellular uptake and cytotoxicity of the anticancer drug doxorubicin. The model assumes sigmoidal, Hill-type dependence of cell survival on drug-induced damage. Experimental evidence indicates distinct intracellular and extracellular mechanisms of doxorubicin...

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Bibliographic Details
Main Authors: El-Kareh, Ardith W, Secomb, Timothy W
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501422/
https://ncbi.nlm.nih.gov/pubmed/16026650
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