Activating Mutations and/or Expression Levels of Tyrosine Kinase Receptors GRB7, RAS, and BRAF in Testicular Germ Cell Tumors

Amplification and/or overexpression of genes encoding tyrosine kinase receptors KIT and ERBB2 have been reported in testicular germ cell tumors (TGCTs). These receptors can bind the adaptor molecule GRB7 encoded by a gene adjacent to ERBB2 at 17q12, a region also frequently gained in TGCTs. GRB7 bin...

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Bibliografiska uppgifter
Huvudupphovsmän: McIntyre, Alan, Summersgill, Brenda, Spendlove, Hayley E, Huddart, Robert, Houlston, Richard, Shipley, Janet
Materialtyp: Artigo
Språk:Inglês
Publicerad: Neoplasia Press Inc. 2005
Ämnen:
Brief Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501174/
https://ncbi.nlm.nih.gov/pubmed/16354586
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