Luminescence Resonance Energy Transfer-Based High-Throughput Screening Assay for Inhibitors of Essential Protein-Protein Interactions in Bacterial RNA Polymerase

The binding of sigma factors to core RNA polymerase is essential for the specific initiation of transcription in eubacteria and is thus critical for cell growth. Since the responsible protein-binding regions are highly conserved among all eubacteria but differ significantly from eukaryotic RNA polym...

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Main Authors: Bergendahl, Veit, Heyduk, Tomasz, Burgess, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150103/
https://ncbi.nlm.nih.gov/pubmed/12620834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.3.1492-1498.2003
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