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Evolutionary and Physiological Importance of Hub Proteins

It has been claimed that proteins with more interaction partners (hubs) are both physiologically more important (i.e., less dispensable) and, owing to an assumed high density of binding sites, slow evolving. Not all analyses, however, support these results, probably because of biased and less-than r...

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Autors principals: Batada, Nizar N, Hurst, Laurence D, Tyers, Mike
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500817/
https://ncbi.nlm.nih.gov/pubmed/16839197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020088
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