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Geldanamycin Treatment Ameliorates the Response to LPS in Murine Macrophages by Decreasing CD14 Surface Expression

Geldanamycin (GA) is an antibiotic produced by Actinomyces, which specifically inhibits the function of the heat shock protein 90 family. Treatment of a murine macrophage cell line (J774) with GA resulted in a reduced response to Escherichia coli lipopolysaccharide (LPS) as visualized by a decrease...

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Autori principali: Vega, Virginia L., De Maio, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150006/
https://ncbi.nlm.nih.gov/pubmed/12589068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-08-0498
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